Abcam, ab241964, Anti-REEP3 antibody

Size: 100µL
Rabbit Polyclonal REEP3 antibody. Suitable for IP and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human REEP3 aa 200 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human REEP3 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q6NUK4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Antibody was affinity purified using an epitope specific to REEP3 immobilized on solid support., Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
REEP3 also known as Receptor Accessory Protein 3 plays an important role in mechanical processes within the cell. This protein assists in shaping the endoplasmic reticulum (ER) by facilitating the stacking and proper organization of the ER membranes. REEP3 has a molecular weight of approximately 28 kDa. Its expression is widespread but shows significant presence in neuronal tissues suggesting a specialized role in these cells.
Biological function summary
REEP3 manages the structural integrity of the endoplasmic reticulum by interacting with other proteins involved in ER morphology. It forms part of a complex that includes microtubule-associated proteins which link the ER to the cytoskeleton enabling proper cellular function. Through this interaction REEP3 supports the maintenance of cellular homeostasis and can influence processes such as protein synthesis and transport.
Pathways
Proteins like REEP3 contribute to ER shaping pathways and cellular stress response mechanisms. It acts alongside proteins like ATLASTIN and SEIPIN in the ER network assembly. Specifically it connects with pathways managing ER stress responses which are vital in adapting to and regulating changes in protein folding demand.
Aberrations in REEP3 function associate with conditions affecting the nervous system such as hereditary spastic paraplegia (HSP). Mutations in REEP3 can lead to defects in ER morphology contributing to neurodegenerative processes. The protein interacts with SPG4 and REEP1 linking it to cytoskeletal abnormalities observed in these disorders. Understanding REEP3's precise role in these pathologies offers potential avenues for therapeutic intervention.