Abcam, ab241967, Anti-PARP12 antibody

Size: 100µg
Rabbit Polyclonal PARP12 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human PARP12 aa 300-350.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human PARP12 aa 300-350. The exact immunogen used to generate this antibody is proprietary information.Q9H0J9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Antibody was affinity purified using an epitope specific to PARP12 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle, Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PARP12 or poly (ADP-ribose) polymerase family member 12 plays a role in post-translational modifications within cells. It functions in mono-ADP-ribosylation a process which affects various proteins' activities by adding ADP-ribose to them. This protein has a calculated mass of approximately 78 kDa. It expresses in various tissues including the liver and immune cells contributing to cellular responses and defense mechanisms.
Biological function summary
Mono-ADP-ribosylation modulates cellular activities affecting processes like viral response and inflammation. PARP12 is part of the broader PARP protein family known for roles in DNA repair and cellular stress responses though PARP12 focuses more on antiviral and stress-related pathways. It does not typically engage in large multi-protein complexes but interacts closely with other molecules within its signaling network to execute its functions.
Pathways
Interactions within antiviral defense mechanisms and inflammation regulation highlight the role of PARP12. It contributes to pathways like the Interferon signaling response enhancing the cell's ability to combat viral infections. Interactions with other PARP family members such as PARP1 and PARP5 further integrate its function into broader cellular immune pathways ensuring a coordinated response to external stressors.
PARP12's involvement predominantly impacts viral infections and inflammatory conditions. It relates to viral response pathways such as those engaged in HIV replication repression highlighting its significance in infectious disease contexts. Furthermore PARP12 connects with proteins like PARP13 in modulating processes involved in immune responses offering insights into managing inflammation-related diseases.