Abcam, ab241992, Anti-TMEM109/Mitsugumin-23 antibody

Size: 100µL
Rabbit Polyclonal TMEM109/Mitsugumin-23 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TMEM109 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TMEM109 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q9BVC6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Antibody was affinity purified using an epitope specific to TMEM109/Mitsugumin-23 immobilized on solid support., Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TMEM109 also known as Mitsugumin-23 (MG23) functions as a transmembrane protein with a mass of approximately 20-25 kDa. It resides in the endoplasmic reticulum membrane where it acts as an important component in maintaining cellular homeostasis. This protein is primarily observed across various tissues with a higher expression in muscle tissue and certain types of epithelial cells. Its structure suggests roles in calcium signaling due to domains that allow ion passage across cellular membranes.
Biological function summary
TMEM109 plays a role in the regulation of calcium ion concentrations within cells contributing to the mitochondrial permeability transition pore (MPTP) complex. This complex controls mitochondrial function by regulating the passage of ions and small metabolites which is critical for cell survival and apoptosis. Through these activities TMEM109 influences processes like muscle contraction and cell death highlighting its significance in cellular energy management and programmed cell death pathways.
Pathways
TMEM109 has roles in calcium signaling and apoptotic pathways two significant biological processes for cellular health. In the calcium signaling pathway it interacts with other proteins such as SERCA1 (Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 1) to help manage calcium ion levels within cells. In apoptotic pathways TMEM109's involvement in the MPTP complex links it to the BAX protein which is an essential regulator of apoptosis facilitating the release of cytochrome c from mitochondria triggering cascade events leading to cell death.
Irregular function or expression of TMEM109 associates with conditions such as muscular dystrophy and neurodegenerative disorders. For example in muscular dystrophy altered calcium regulation and signaling through MG23 may impact muscle contraction and integrity. Additionally abnormal TMEM109 activity can connect to Alzheimer’s disease where disrupted calcium homeostasis and apoptotic signaling play roles. These disease connections make TMEM109 a considerable target for therapeutic research and intervention often intersecting pathways with proteins like dystrophin in muscular dystrophy cases and amyloid precursor protein (APP) in Alzheimer's disease.