Abcam, ab243027, Anti-ITGA8 antibody [CL7304]

Size: 100µL
Mouse Monoclonal ITGA8 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ITGA8 aa 800-950.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:CL7304,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ITGA8 aa 800-950. The exact immunogen used to generate this antibody is proprietary information.P53708

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Purification notes-Purified from TCS., Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Integrin alpha-8 (ITGA8) is a protein belonging to the integrin family primarily involved in cell adhesion and signaling. It forms a heterodimer with beta-1 integrin subunit to mediate interactions between cells and the extracellular matrix. The molecular mass of ITGA8 is approximately 131 kDa. ITGA8 is expressed in several tissues most notably in the kidney lung and nervous system suggesting its role in organ development and function.
Biological function summary
The role of ITGA8 in cellular processes includes mediating cell adhesion and migration. It functions as part of the integrin complex which plays a critical role in transmitting mechanical signals from the extracellular matrix to the cell interior. The integrin complex influences various cellular behaviors such as cell shape motility and proliferation which are essential for tissue organization and repair.
Pathways
ITGA8 integrally participates in the extracellular matrix (ECM) and focal adhesion signaling pathways. These pathways are important for maintaining cellular structure and promoting communication between cells and their environment. ITGA8 shares functional relationships with other proteins in these pathways such as fibronectin and collagen enhancing its importance in regulatory networks that govern cell adhesion and migration.
ITGA8 has shown an association with kidney fibrosis and neuronal development disorders. Dysfunction in ITGA8 expression or signaling can contribute to pathological processes like fibrosis where excessive ECM deposition leads to tissue scarring and impaired organ function. Additionally connections between ITGA8 and related proteins such as beta-1 integrin can influence disease progression and potential therapeutic targeting in these conditions.