Abcam, ab243451, Anti-MYO9B antibody

Size: 100µL
Rabbit Polyclonal MYO9B antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MYO9B aa 1350-1500.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MYO9B aa 1350-1500. The exact immunogen used to generate this antibody is proprietary information.Q13459

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein MYO9B also known as myosin IXb is part of the unconventional myosin family and has a molecular mass of approximately 290 kDa. It is an actin-based motor protein that operates in the cellular cytoskeleton to facilitate various cellular processes. MYO9B is expressed in tissues such as the kidney liver and particularly high in the intestinal epithelium where it plays critical roles in maintaining cell shape and motility.
Biological function summary
MYO9B modulates the dynamics of the actin cytoskeleton influencing cell movement and polarity. This myosin acts as a molecular motor converting chemical energy into mechanical work driving intracellular transport and signaling processes. It also contains a Rho GTPase-activating protein (RhoGAP) domain implicating it in the regulation of Rho family GTPases which are pivotal for actin organization. MYO9B does not function alone but interacts with other proteins within molecular complexes to maintain cellular integrity.
Pathways
MYO9B participates in signaling cascades that control cytoskeleton rearrangement and cellular adhesion. Notably MYO9B plays roles in the RhoA signaling pathway essential for actin-myosin organization and cellular contraction. It accomplishes this by acting in opposition to proteins like ROCK1 impacting cellular tension and morphology.
Alterations in MYO9B have been linked to inflammatory bowel disease (IBD) and celiac disease. MYO9B interacts with other proteins involved in maintaining intestinal barrier function notably TGF-beta signaling components that play a role in gut immune responses. Dysregulation in this protein affects epithelial cell function contributing to the pathogenesis of these gastrointestinal disorders.