Abcam, ab243457, Anti-MEX3C antibody

Size: 100µL
Rabbit Polyclonal MEX3C antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MEX3C aa 450-550.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MEX3C aa 450-550. The exact immunogen used to generate this antibody is proprietary information.Q5U5Q3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The biological target MEX3C also known as RKHD3 or MEX-3 homolog C is a protein that functions mechanically as an RNA-binding protein. It has a mass of approximately 73 kilodaltons. MEX3C is expressed in various tissues including the brain skeletal muscle and kidney. It contains KH domains responsible for binding RNA enabling it to regulate the fate of specific mRNA molecules influencing mRNA stability and translation.
Biological function summary
MEX3C acts as a post-transcriptional regulator and is involved in mRNA decay and modulation. It does not appear to be a part of any large protein complexes but regulates the expression of a variety of cellular factors by binding target mRNAs. This control mechanism allows MEX3C to influence cell differentiation and development by affecting protein synthesis at the post-transcriptional level.
Pathways
MEX3C is implicated in the regulation of the Wnt signaling pathway and the mRNA surveillance pathway. It interacts with proteins involved in these pathways to modulate transcriptional outputs and cell signaling processes which are vital for normal embryonic development and cellular homeostasis. Proteins such as β-catenin and UPF1 may interact with MEX3C as part of these pathways aligning MEX3C actions with control of cell proliferation and gene expression.
MEX3C has connections to cancer particularly in pathways that influence tumor growth and progression. Additionally MEX3C may play a role in neurodegenerative diseases as it is involved in mRNA regulation within neurons. Disorders linked with MEX3C involve proteins like p53 which is associated with the regulation of cell cycle and apoptosis illustrating the potential impact of MEX3C on cellular outcomes that pertain to these diseases.