Abcam, ab243505, Anti-CHCH antibody

Size: 100µL
Rabbit Polyclonal CHCH antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CHURC1 aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CHURC1 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q8WUH1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The CHCH domain-containing protein also known as CHCHD plays a mechanical role within the cell by being involved in mitochondrial processes. It has a mass of approximately 15 kDa. This protein is expressed in various tissues with high levels in the heart and skeletal muscles. It localizes to the mitochondria where it interacts with other mitochondrial proteins to maintain cellular function.
Biological function summary
The CHCHD protein participates in the assembly and stabilization of protein complexes within the mitochondria. It serves as a component of the mitochondrial intermembrane space bridging complex (MIB) facilitating electron transfer processes necessary for cellular respiration. The stability of the complex is essential for maintaining the proper mitochondrial bioenergetics that influence overall cellular health.
Pathways
The CHCHD protein is an important player in mitochondrial respiration and apoptosis pathways. It interacts with cytochrome c during the electron transport chain which is important for ATP production. This protein also relates to apoptosis through interactions that influence the release of pro-apoptotic factors like c-caspases supporting the balance between cell survival and programmed cell death.
The CHCHD protein associates with neurodegenerative diseases such as Parkinson's disease where its dysfunction contributes to mitochondrial abnormalities. It also connects with cardiac disorders since it influences the mitochondrial pathways important for heart function. In Parkinson's disease alterations in interactions between CHCHD and proteins like CHCHD2 have been implicated highlighting the protein's role in mitochondrial health and disease.