Abcam, ab243591, Anti-POLR1D antibody

Size: 100µL
Rabbit Polyclonal RPC22 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
POLR1D also known as RNA polymerase I and III subunit D is a component of the RNA polymerase I and III complexes. It weighs approximately 16.5 kDa. This protein is important for the transcription of ribosomal RNA (rRNA) and small RNA molecules. It is primarily expressed in cells that have high transcriptional activity such as in tissues like the pancreas thymus and spleen.
Biological function summary
The activity of POLR1D contributes to the formation of ribosomal RNA an essential component of the ribosome which is responsible for protein synthesis. POLR1D forms part of both RNA Polymerase I and RNA Polymerase III complexes which are responsible for transcribing rRNA and other small RNAs respectively. It interacts closely with other subunits within these complexes to facilitate transcription processes.
Pathways
POLR1D plays a role in the rRNA transcription pathway and the RNA polymerase I promoter opening pathway. Its function is essential within these pathways to initiate and sustain the transcription required for ribosome production. POLR1D is related to other subunits of RNA polymerases like POLR1A and POLR1B through these pathways forming an interconnected network essential for nucleolar function and RNA maturation.
Malfunction or mutations within POLR1D can lead to Treacher Collins syndrome which is a disorder affecting craniofacial development. This connection highlights the importance of properly functioning RNA polymerases for developmental processes. Additionally disturbances in POLR1D have been studied in relation to leukemias where disrupted transcription processes can contribute to uncontrolled cell proliferation and cancer. POLR1D's role in these diseases highlights its importance in maintaining normal cellular operation and development.