Abcam, ab243713, Anti-ARHGAP11A antibody

Size: 100µL
Rabbit Polyclonal ARHGAP11A antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ARHGAP11A aa 400-500.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ARHGAP11A aa 400-500. The exact immunogen used to generate this antibody is proprietary information.Q6P4F7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ARHGAP11A also known as Rho GTPase-activating protein 11A mainly functions as a Rho GTPase-activating protein. It influences the Rho family of small GTPases by converting them from an active GTP-bound state to an inactive GDP-bound state. This protein has an approximate mass of 102 kDa. Human tissues such as the brain and testes highly express ARHGAP11A while other tissues show lower expression levels.
Biological function summary
ARHGAP11A plays a role in cell division and cytoskeletal organization by interacting with Rho GTPases. It operates as part of regulatory networks affecting cytoskeletal dynamics essential for cellular shape and motility. Studies suggest that it may form complexes with other proteins that modulate actin filament assembly thereby aiding in processes like cell migration and mitotic spindle formation.
Pathways
ARHGAP11A influences cellular pathways that involve cytoskeletal reorganization and cell cycle regulation. The Rho signaling pathway involves ARHGAP11A controlling actin cytoskeleton reformation. It interacts with other proteins like RhoA influencing signal transduction processes. The precise modulation of cytoskeletal signaling indicates ARHGAP11A’s critical role in various cellular activities.
ARHGAP11A associates with neurodevelopmental disorders due to its expression in brain tissues implicating it in brain development processes. Aberrations in its regulation may contribute to cancer progression via dysregulation of cell migration and invasion pathways. Connections with other proteins like RhoA link ARHGAP11A to these disorders underpinning its involvement in disease mechanisms.