Abcam, ab243719, Anti-Syntaxin 6 antibody - Golgi Membrane Marker

Size: 100µL
Rabbit Polyclonal Syntaxin 6 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human STX6 aa 50-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human STX6 aa 50-200. The exact immunogen used to generate this antibody is proprietary information.O43752

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Syntaxin 6 also known as STX6 functions as a SNARE protein involved in vesicle fusion processes. It has a molecular weight of about 31 kDa. You find it mainly in the trans-Golgi network and within endosomal compartments. Syntaxin 6 varies in expression across different tissues but exhibits strong presence in the brain and lung. This protein plays an important role in intracellular trafficking by mediating fusion of transport vesicles with their correct target membranes.
Biological function summary
Syntaxin 6 contributes to intracellular material transport and acts as a component of the SNARE complex which includes other proteins like Vti1a and VAMP4. These SNARE complexes facilitate vesicle docking and fusion important for cargo delivery. In particular Syntaxin 6 aids in routing proteins and lipids from the Golgi apparatus to their destinations supporting normal cellular function and maintenance of cellular organelles.
Pathways
Syntaxin 6 involves itself in endocytosis and the secretory pathway. It interacts with proteins such as syntaxin 16 and Vti1b coordinating vesicular traffic from the Golgi to endosomes and lysosomes. Proper function of these pathways maintains cellular homeostasis and impacts processes like hormone secretion and receptor recycling making Syntaxin 6 integral for efficient cellular communication and transport.
Dysregulation of Syntaxin 6 links to neurodevelopmental disorders and cancer progression. Abnormal Syntaxin 6 expression can affect neurotransmitter release highlighting its relationship with proteins like VAMP2 in neurological disorders. Further alterations in its function impact cellular proliferation contributing to oncogenic processes through interactions with proteins such as SNAP23. Understanding its role in these contexts emphasizes the need for further research to explore therapeutic implications.