Abcam, ab243721, Anti-HOXC11 antibody

Size: 100µL
Rabbit Polyclonal HOXC11 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human HOXC11 aa 1-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human HOXC11 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.O43248

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HOXC11 also known as Homeobox C11 is a protein that functions as a transcription factor. It belongs to the homeobox gene family and plays a role in regulating gene expression. HOXC11's molecular weight is approximately 34 kDa. This protein is mainly expressed in tissues like the breast prostate and placenta. Through DNA binding HOXC11 influences cellular processes by controlling the expression of various downstream target genes.
Biological function summary
HOXC11 acts as a regulator of embryonic development and differentiation. It forms part of the HOX gene complex that significantly contributes to the establishment of body plans and organogenesis. HOXC11 influences cellular proliferation and differentiation playing a critical role during morphogenetic events. The protein's expression patterns suggest its involvement in developing specific tissues leading to precise anatomical structures.
Pathways
The actions of HOXC11 integrate into important signaling cascades notably the Wnt signaling and retinoic acid pathways. Within the Wnt pathway HOXC11 interacts with other homeobox proteins to modulate gene expression and influence cell fate decisions. In the context of the retinoic acid pathway HOXC11 collaborates with proteins like HOXA9 to regulate the expression of genes involved in cellular differentiation and development. These pathways highlight HOXC11's function in finely tuning gene networks necessary for proper embryogenesis and tissue homeostasis.
Aberrant HOXC11 expression has associations with breast cancer and prostate cancer. In breast cancer abnormal regulation of HOXC11-linked genes may contribute to tumor progression. In prostate cancer HOXC11 interacts with AR (androgen receptor) influencing cancer cell growth and survival. Researchers focus on targeting the interaction of HOXC11 with other proteins to develop potential therapeutic approaches for treating these cancers.