Abcam, ab243732, Anti-ITFG2 antibody

Size: 100µL
Rabbit Polyclonal ITFG2 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human KICSTOR complex protein ITFG2 aa 200-350.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human KICSTOR complex protein ITFG2 aa 200-350. The exact immunogen used to generate this antibody is proprietary information.Q969R8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein ITFG2 or Integrin Alpha FG-GAP Repeat Containing 2 plays an essential role in cell adhesion and migration mechanisms. Its molecular mass is approximately 42 kDa. Researchers have identified ITFG2 expression in various tissues including the heart brain liver and skeletal muscle indicating its potential involvement in diverse physiological processes.
Biological function summary
ITFG2 contributes to cell-cell interaction and signaling. It acts as part of the integrin protein family which facilitates communication between cells and their surrounding environment. The protein participates in processes involving cell adhesion through forming complexes with other integrins influencing cellular responses. ITFG2 by interacting with other cellular components supports the maintenance of cell structure and tissue architecture.
Pathways
ITFG2's function integrates into significant biological pathways notably the integrin-mediated signaling pathway and focal adhesion pathway. These pathways involve cooperation with other proteins like integrin beta subunits which assist in transmitting signals that affect cell proliferation survival and differentiation. ITFG2's contribution to these pathways highlights its involvement in essential cellular events and homeostasis.
ITFG2 is linked to certain pathological conditions due to its role in cellular communication. Abnormal expression of ITFG2 has been associated with cancer progression as it may alter cell adhesion properties promoting metastasis. Additionally researchers are investigating its connection to cardiovascular diseases given its expression in heart tissue and interaction with integrin-related proteins in these contexts. Understanding ITFG2's function may therefore provide insights into therapeutic strategies for these conditions.