Abcam, ab244267, Anti-MEIS2 antibody

Size: 100µL
Rabbit Polyclonal MEIS2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MEIS2 aa 150-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MEIS2 aa 150-300. The exact immunogen used to generate this antibody is proprietary information.O14770

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MEIS2 or Myeloid Ecotropic Viral Integration Site 2 is a transcription factor known for its role in gene regulation. This protein weighs approximately 52-54 kDa and participates in DNA binding. MEIS2 is highly expressed in tissues like the brain heart and kidneys especially during developmental stages. MEIS2 functions through direct interaction with genomic regions to regulate the transcription of target genes.
Biological function summary
MEIS2 influences cell differentiation and organ development. It interacts with other proteins as part of a complex including the HOX and PBX families to fine-tune transcriptional outcomes. MEIS2 plays a role in neuronal development where its activity helps shape the neural tissue architecture. Researchers observe that MEIS2 affects cellular processes important for forming correctly structured organs.
Pathways
MEIS2 is engaged in the retinoic acid signaling pathway and the Notch signaling pathway. These pathways are vital in embryonic development and cellular differentiation. MEIS2's interaction with the PBX1 protein demonstrates its importance in pathways that lead to precise gene expression during development. Together they contribute to regulating the transcriptional networks involved in developmental processes.
MEIS2 has links to certain developmental disorders and cancers. Mutations or aberrant expression of MEIS2 correlate with conditions like cleft palate and neuroblastoma. Notably its interaction with the HOXA9 protein has been documented in certain types of leukemia showing how MEIS2-related pathways can contribute to abnormal cell proliferation. Understanding these interactions aids research into potential targets for therapeutic intervention.