Abcam, ab244286, Anti-ADNP antibody

Size: 100µL
Rabbit Polyclonal ADNP antibody. Suitable for IHC-P, ICC, WB and reacts with Human, Rat, Mouse samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ADNP aa 850-1050.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, WB, ICCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ADNP aa 850-1050. The exact immunogen used to generate this antibody is proprietary information.Q9H2P0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The ADNP protein also known as Activity-dependent neuroprotector homeobox is a multifunctional protein with a mass of about 123 kDa. ADNP is highly expressed in the brain but also present in other tissues including heart and kidney. It regulates neural development and synaptic plasticity by interacting with chromatin and participating in transcriptional activities. The protein plays a role in cell cycle regulation and is involved in neuroprotection against multiple insults.
Biological function summary
ADNP plays critical roles in the development of the nervous system and maintenance of neuronal function. As part of a chromatin remodeling complex known as SWI/SNF it modulates the expression of genes necessary for neurogenesis and neuronal survival. ADNP affects microtubule dynamics which are important for neuron structure and transport by regulating activity of associated proteins. These functions make ADNP influential in maintaining a healthy nervous system and protecting against neurodegenerative processes.
Pathways
ADNP is necessary for proper functioning in neuroprotective pathways and the regulation of gene expression pathways. It closely interacts with the proteins REST and HDAC2 in the regulation of transcription important for neuronal cell survival. The involvement in Wnt signaling pathway an important regulator of cell proliferation and differentiation highlights its importance in neural development and plasticity. ADNP also affects the activity of MAPK/ERK pathway which links it to the control of cell proliferation and survival.
ADNP mutations or dysregulations have been connected to neurodevelopmental disorders such as Helsmoortel-Van der Aa syndrome and Alzheimer's disease. In relation to Helsmoortel-Van der Aa syndrome disruptions in ADNP lead to intellectual disability and developmental delays due to impaired neural growth. In Alzheimer's disease changes in ADNP expression affect the stability and function of tau a protein involved in neurofibrillary tangles. These interactions underline ADNP's significance in neuropsychiatric disorders and potential as a therapeutic target.