Abcam, ab244318, Anti-MGAT5 antibody

Size: 100µL
Rabbit Polyclonal MGAT5 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MGAT5 aa 600 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MGAT5 aa 600 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q09328

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MGAT5 also known as beta-16-N-acetylglucosaminyltransferase V or GnT-V is an enzyme with a molecular mass of approximately 83 kDa. This enzyme plays a role in the Golgi apparatus where it modifies N-glycans on glycoproteins by adding N-acetylglucosamine to N-glycans. MGAT5 is expressed in various tissues including the brain liver and kidneys. Its enzymatic function is essential in creating complex branched glycan structures influencing the cellular surface glycosylation patterns.
Biological function summary
MGAT5 contributes to cellular processes such as cell-cell communication cell migration and signal transduction. These processes are important in tissues where it is expressed. MGAT5 is not part of a complex but works closely with other glycosyltransferases in the glycosylation pathway. Its glycan products interact with lectins and receptors on the cell surface influencing signaling pathways and cellular behavior.
Pathways
MGAT5 is significant in the glycosylation pathway and the PI3K/AKT signaling pathway. In these pathways MGAT5 modifies glycoproteins which can impact receptor function and downstream signaling. It interacts with proteins such as integrins and growth factor receptors affecting cellular responses to environmental cues and influencing growth and differentiation signals.
MGAT5 is associated with cancer progression and autoimmune diseases. Altered MGAT5 expression and activity in cancer cells can promote tumor growth and metastasis by enhancing cell invasion and evasion mechanisms. The enzyme links to proteins like TGF-beta receptor and E-cadherin in cancer contributing to the changes in cellular adhesion and signaling that facilitate metastasis. In autoimmune diseases MGAT5 modulates immune cell function impacting disease progression and severity.