Abcam, ab244412, Anti-CASZ1 antibody

Size: 100µL
Rabbit Polyclonal CASZ1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human CASZ1 aa 150-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CASZ1 aa 150-300. The exact immunogen used to generate this antibody is proprietary information.Q86V15

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CASZ1 also known as Castor zinc finger 1 is a transcription factor with a molecular mass around 131 kDa. It contains zinc finger motifs which allow it to bind DNA and regulate gene expression. This protein is ubiquitously expressed prominently found during development in tissues like the heart brain and vascular systems. CASZ1 plays an important role in cellular processes through its regulatory actions.
Biological function summary
This transcription factor influences cardiovascular development and neural differentiation. It is part of no known complex but interacts with other proteins for its function. CASZ1 regulates gene networks that are necessary for proper cell cycle progression and differentiation. Its presence ensures cells develop with the right timing and destinations especially in tissues demanding precise regulation.
Pathways
CASZ1 integrates into significant developmental pathways. It participates in the Notch signaling pathway important for vascular development and heart formation. Through these pathways CASZ1 interacts with other proteins such as Notch receptors and Delta ligands. This linkage helps synchronize gene expression for tissue-specific development.
CASZ1 links to congenital heart disease and neuroblastoma. Mutations or deregulation in CASZ1 expression have been associated with improper heart formation in congenital defects. In neuroblastoma its dysregulation alters cellular differentiation. CASZ1 interacts with proteins like MYCN in neuroblastoma relating to the malignancy's progression. Understanding CASZ1's roles could reveal therapeutic targets for these conditions.