Abcam, ab244422, Anti-GBP5 antibody

Size: 100µL
Rabbit Polyclonal GBP5 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human GBP5 aa 450 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human GBP5 aa 450 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q96PP8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GBP5 or Guanylate Binding Protein 5 serves an important role in the immune response particularly within the innate immune system. GBP5 is a GTPase with a molecular mass of approximately 71 kDa. It expresses in a variety of tissues including immune cells like macrophages and lymphocytes. Its mechanical function involves binding to guanosine triphosphate (GTP) and converting it to guanosine diphosphate (GDP) a process which then triggers further downstream immune responses.
Biological function summary
GBP5 acts in immune defense against intracellular pathogens. It forms part of a multiprotein complex that can directly target and destroy bacterial membranes. GBP5 enhances the cell-autonomous immunity by promoting inflammasome activation which boosts cytokine production leading to a stronger inflammatory response. Its activity reflects in the ability of immune cells to restrict the growth of certain pathogens hence forming an important part of the host defense mechanism.
Pathways
GBP5 is part of the interferon-gamma signaling pathway. This pathway engages in regulating immune responses during infections particularly by modulating the activity of other immune-related proteins such as GBP1 and GBP2. GBP5 links to the NF-kB pathway as well where it helps regulation of inflammatory responses. The efficient functioning of these pathways ensures that immune responses remain robust and effective against pathogens.
GBP5 is linked to tuberculosis and Crohn’s disease. Its role in immune responses impacts how efficiently the body can deal with intracellular mycobacterial infections typical of tuberculosis. In Crohn’s disease GBP5 associates with inflammatory processes that drive pathology. Through these conditions GBP5 often interfaces with proteins like NOD2 which shares a similar role in recognizing and responding to microbial components.