Abcam, ab244451, Anti-ECM antibody

Size: 100µL
Rabbit Polyclonal ECM antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MMRN1 aa 650-800.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MMRN1 aa 650-800. The exact immunogen used to generate this antibody is proprietary information.Q13201

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The extracellular matrix (ECM) constitutes a complex network of macromolecules such as proteins and glycoproteins including the key structural proteins like collagen elastin fibronectin and laminin. It provides structural support to cells and tissues and plays a role in signal transmission across the cellular environment. The ECM does not have a singular mass due to its diverse composition but is expressed throughout different tissues in the body. Its complexity and vast distribution are essential for maintaining tissue architecture and function.
Biological function summary
The extracellular matrix coordinates cellular functions by mediating mechanical and biochemical signals influencing cellular processes such as adhesion differentiation and migration. The ECM is an essential component of the matrix receptor complex interacting dynamically with cell-surface receptors like integrins. These interactions are important to tissue remodeling and repair allowing tissues to maintain homeostasis and respond to external stresses.
Pathways
The extracellular matrix participates in significant biological pathways like the integrin signaling pathway and the Wnt signaling pathway. These pathways link ECM to various cellular responses affecting processes such as cell migration proliferation and survival. Integrin proteins for example bind to ECM proteins transmitting signals that can regulate gene expression and determine cell fate. Disruption in these pathways has implications for developmental processes and disease states.
The extracellular matrix plays a role in conditions such as fibrosis and cancer. Alterations in ECM components or remodelling can lead to fibrotic diseases where excessive ECM deposition affects tissue function. In cancer ECM changes can influence tumor progression and metastasis. Matrix metalloproteinases (MMPs) a group of enzymes breaking down ECM proteins connect ECM to these pathological states altering tissue integrity and facilitating disease progression. Understanding ECM dynamics is therefore essential for developing therapeutic strategies against these disorders.