Abcam, ab244538, Anti-PIAS2 antibody

Size: 100µL
Rabbit Polyclonal PIAS2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PIAS2 aa 550 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PIAS2 aa 550 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O75928

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein PIAS2 also known as Protein Inhibitor of Activated STAT2 plays an active role in regulating gene expression by modifying the activity of specific transcription factors. It is a member of the PIAS family and its molecular mass is approximately 71 kDa. Scientists have observed PIAS2 expression in various tissues including the brain heart and skeletal muscle suggesting its widespread importance across different cell types. This protein can bind to specific target proteins exerting its influence primarily through SUMOylation an essential post-translational modification process.
Biological function summary
PIAS2 regulates several cellular processes by modulating transcription factor activity. It acts as a co-regulator in various cellular contexts forming part of larger protein complexes. Through these interactions it manages immune responses cell cycle progression and apoptosis. PIAS2 is particularly active in controlling the balance of STAT signaling which affects numerous biological functions. By enhancing or repressing particular transcription factors PIAS2 can shape cellular outcomes important for normal development and function.
Pathways
PIAS2 plays an important role in controlling important signaling cascades including the JAK/STAT and TGF-beta pathways. Within these pathways it influences diverse biological processes from immune regulation to tissue repair. PIAS2 interacts with other proteins like STAT2 and SMADs that participate in these pathways integrating signals it receives and transmitting them to execute physiological responses. These interactions highlight PIAS2's multifaceted roles in mediating signal transduction and maintaining cellular homeostasis.
PIAS2 displays connections to cancer and autoimmune diseases. Altered PIAS2 function or expression can lead to aberrations in STAT signaling which may contribute to oncogenesis or impaired immune regulatory mechanisms. It has interactions with proteins such as p53 and STAT factors which link PIAS2 to pathways frequently disrupted in these conditions. Understanding PIAS2's involvement in these diseases highlights the potential for therapeutic targeting to mitigate disease progression or augment treatment strategies.