Abcam, ab245643, Anti-WDR62 antibody

Size: 100µL
Rabbit Polyclonal WDR62 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human WDR62 aa 900-950.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human WDR62 aa 900-950. The exact immunogen used to generate this antibody is proprietary information.O43379

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab245643 was affinity purified using an epitope specific to WDR62 immobilized on solid support., Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
WDR62 also known as WD repeat-containing protein 62 is a protein with a molecular mass of approximately 152 kDa. It localizes predominantly in the cytoplasm and the spindle poles of dividing cells. The protein contains several WD40 repeats which are motifs critical for protein-protein interactions. WDR62 is expressed in various tissues including the brain suggesting a significant function in neural development.
Biological function summary
WDR62 plays an essential role in neurogenesis by influencing cell proliferation and differentiation. It is a component of the spindle assembly complex ensuring proper chromosomal segregation during cell division. The protein is particularly active during mitosis where it participates in establishing spindle pole organization. Proper function of WDR62 is necessary for maintaining the integrity of the neuronal population in the developing brain.
Pathways
Spindle assembly and mitotic progression heavily involve WDR62. It interacts with Aurora A kinase an important player in the mitotic checkpoint pathway allowing accurate chromosome alignment and segregation. WDR62 also associates with c-Jun N-terminal kinase (JNK) signaling which impacts cell cycle regulation and apoptosis. These interactions suggest that WDR62 plays a role in ensuring normal cell division and viability.
Mutations in WDR62 often lead to microcephaly a condition characterized by reduced brain size and intellectual disability. This link highlights the protein's critical function in brain development. Additionally aberrations in WDR62 might contribute to epileptic syndromes reflecting its involvement in neuronal health. In these disorders it interacts with proteins such as ASPM and CEP152 which are also implicated in microcephaly and cortical malformations.