Abcam, ab245684, Anti-EDAR antibody [EDAR12]

Size: 200µg
Rabbit Monoclonal EDAR antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Protein within Mouse Edar.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EDAR12,
Isotype:IgG,
Light chain type:kappa,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Protein within Mouse Edar. The exact immunogen used to generate this antibody is proprietary information.Q9R187,
Epitope:CRD1 of the extracellular domain of EDAR.,
Specificity:EDAR12 recognises and binds to CRD1 of the extracellular domain of mouse EDAR. EDAR3 cross-reacts with EDAR derived from human, dog, rat and chicken when EDAR is fused to the glycosylphosphatidylinositol anchor of TRAILR3. EDAR is the receptor for the TNF family ligand EDA1, which is a type II transmembrane protein possessing a collagen-like domain and a C-terminal TNF-homology domain. EDAR is important for the correct development of skin appendages including hair, teeth and eccrine sweat glands. LoF mutations in the Eda gene is known to cause XLHED (X-linked hypohidrotic ectodermal dysplasia), and results in abnormal development.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.02% Proclin 300Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The ectodysplasin A receptor also known as EDAR is a transmembrane protein involved in various developmental processes. It has a molecular mass of approximately 63 kDa. You can find EDAR expression in tissues such as the skin hair follicles and teeth. As a member of the tumor necrosis factor receptor (TNFR) family EDAR plays an important mechanical role by binding ectodysplasin A ligand (EDA) which initiates downstream signals important for developmental pathways.
Biological function summary
The interaction between EDAR and its ligand EDA influences morphogenesis of ectodermal-derived structures. This receptor-ligand binding is integral to the EDAR/NF-kappaB signaling complex. It affects processes such as the formation of hair follicles sweat glands and teeth. The receptor facilitates cell communication necessary for the proper development of these structures ensuring the correct activation of related signaling pathways.
Pathways
EDAR functions within the NF-kappaB and Wnt signaling pathways. These pathways regulate cellular differentiation and proliferation. The receptor collaborates with adapter proteins such as EDARADD to effectively transmit signals downstream. Furthermore it shares significant relationships with other TNF receptor family members highlighting the importance of signaling specificity and coordination within these biological pathways.
Mutations in the EDAR gene associate with ectodermal dysplasia a genetic disorder affecting hair teeth and sweat glands. Additionally EDAR influences the development of hypohidrotic ectodermal dysplasia (HED). The receptor's link with EDA and other TNFR family members highlights the complex genetic interactions contributing to these conditions. Understanding these relationships provides insights into targeted therapeutic strategies addressing developmental abnormalities.