Abcam, ab24609, Anti-Nuclear Pore Complex Proteins antibody [Mab414]

Size: 100µL
Anti-Nuclear Pore Complex Proteins antibody [Mab414] (ab24609) is a mouse monoclonal antibody detecting Nuclear Pore Complex Proteins in Western Blot, IHC-P, ICC/IF . Suitable for Human, Mouse, Rat, Saccharomyces cerevisiae . - Over 170 publications - Trusted since 2005
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:Mab414,
Isotype:IgG1,
Carrier free:No,
Reacts with:Mouse, Human, Saccharomyces cerevisiae, Rat,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Product details:
What is this antibody validated in?
Anti-Nuclear Pore Complex Proteins antibody [Mab414] (ab24609) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Mouse, Rat, Saccharomyces cerevisiae samples.
Trusted by the scientific community
Anti-Nuclear Pore Complex Proteins [Mab414] (ab24609) was first used in a scientific publication in 2005 and has been cited over 170 times in peer-reviewed journals.
Reviewed by scientists
Anti-Nuclear Pore Complex Proteins [Mab414] (ab24609) has over 10 independent reviews from customers.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-Preservative: 0.03% Thimerosal (merthiolate)Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Nuclear Pore Complex Proteins often called pore proteins or NPC proteins are large structures that form channels in the nuclear envelope. These proteins have a mass of about 120 MDa. They are expressed in the nuclear envelope of eukaryotic cells. NPC proteins function as gates for molecules traveling in and out of the nucleus regulating the entry and exit of proteins RNA and other macromolecules. Alternative names like 'pore complex' and 'nucleus pores' are sometimes used to describe these structures.
Biological function summary
NPC proteins enable the exchange of molecules between the nucleus and the cytoplasm. They are part of the NPC complex integrating several different proteins in a highly coordinated manner. These proteins manage transport through nuclear pore by selectively allowing the passage of certain molecules while blocking others. This selective permeability ensures that essential cellular processes such as DNA replication and transcription occur efficiently within the nucleus.
Pathways
NPC proteins participate significantly in nucleocytoplasmic transport pathways and gene expression regulation pathways. They are involved with proteins like importins and exportins that mediate the transport of molecules across the nuclear envelope. Importin Β for example facilitates the transport of proteins into the nucleus while exportin mediates the export of RNA and ribonuclear proteins.
Alterations in NPC proteins have links to specific conditions such as cancer and neurodegenerative diseases. Abnormalities in NPC function are associated with the mislocalization of proteins and RNA contributing to disease pathogenesis. One protein related to these disorders is TPR (Translocated Promoter Region) which can interact with NPC proteins and has roles in cell cycle regulation and chromatin organization.