Abcam, ab246883, Anti-PSMD8 antibody

Size: 100µL
Rabbit Polyclonal PSMD8 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human, Mouse, Rat samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human 26S proteasome non-ATPase regulatory subunit 8 aa 200 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human 26S proteasome non-ATPase regulatory subunit 8 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P48556

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PSMD8 also known as proteasome 26S subunit non-ATPase 8 is a component of the 19S regulatory particle of the proteasome complex. This protein has a molecular mass of approximately 37 kDa. It facilitates protein degradation by recognizing ubiquitin-tagged substrates important for maintaining protein homeostasis. Researchers have identified its expression in various tissues including liver kidney and heart and it plays a significant role in cellular processes that require regulated protein turnover.
Biological function summary
PSMD8 contributes to the assembly and function of the 26S proteasome which is a multi-subunit complex responsible for degrading ubiquitinated proteins. It acts as a part of the regulatory particle enabling substrate recognition and unfolding. Through its function PSMD8 is involved in the ubiquitin-proteasome system which is key in cellular regulation mechanisms such as cell cycle control apoptosis and DNA repair. This highlights its importance in maintaining cell function and integrity.
Pathways
Protein homeostasis and degradation represent important pathways in which PSMD8 participates. It plays a role in the ubiquitin-proteasome pathway interacting with proteins within this system like Rpn11 and Rpt5 which are also parts of the proteasome complex. Additionally the involvement of PSMD8 in the protein degradation pathway links it to the regulation of transcription factors influencing various signaling pathways that control cell proliferation and differentiation.
PSMD8 has implications in neurodegenerative diseases and cancer as disruptions in proteasome functions are often related to these conditions. Altered proteasome activity can lead to the accumulation of misfolded or damaged proteins which is a hallmark of neurodegenerative diseases such as Parkinson's disease. Moreover in cancer PSMD8's role in protein degradation can affect cell cycle regulation working in connection with proteins like p53. These relationships make PSMD8 an interesting target for therapeutic interventions in proteasome-related diseases.