Abcam, ab246940, Anti-PSMD12 antibody

Size: 100µL
Rabbit Polyclonal PSMD12 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PSMD12 aa 250-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PSMD12 aa 250-400. The exact immunogen used to generate this antibody is proprietary information.O00232

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PSMD12 also known as proteasome 26S subunit non-ATPase 12 is a component of the 19S proteasome regulatory particle which is involved in the degradation of ubiquitinated proteins. The protein has a calculated mass of approximately 39 kDa. Researchers have found PSMD12 in a wide range of tissues indicating its broad expression across different cell types. It plays a significant role in the ubiquitin-proteasome system influencing several cellular processes.
Biological function summary
PSMD12 functions as an integral part of the proteasome complex. The proteasome which includes PSMD12 plays a critical role in the regulated degradation of damaged or unnecessary proteins thereby maintaining protein homeostasis within cells. This process is essential for regulating various cellular functions such as cell cycle apoptosis and DNA repair. Through its involvement in protein degradation PSMD12 indirectly influences transcriptional regulation and signal transduction.
Pathways
PSMD12 synthesis participates actively in the ubiquitin-proteasome pathway and is associated with cell cycle regulation. The protein's involvement in these pathways underlines its important interaction with other proteasome subunits like PSMD1 and PSMD2. Additionally PSMD12's contribution to the NF-kB signaling pathway suggests its influence on genes responsible for immune and inflammatory responses.
PSMD12 takes part in processes relevant to cancer development and neurodegenerative diseases such as Alzheimer's disease. Altered regulation of the proteasome function involving PSMD12 and related proteins like PSMD7 has been implicated in tumorigenesis where protein degradation pathways become disrupted. Furthermore in Alzheimer’s impaired proteasome activity including the function of components like PSMD12 has been linked to the accumulation of protein aggregates commonly observed in these neurodegenerative disorders.