Abcam, ab246987, Anti-SAMM50/SAM50 antibody

Size: 100µL
Rabbit Polyclonal SAMM50/SAM50 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human, Mouse, Rat samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SAMM50 aa 1-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SAMM50 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.Q9Y512

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SAMM50 also known as SAM50 is an important component in mitochondrial function. This protein is part of the sorting and assembly machinery (SAM) complex and is necessary for the insertion of β-barrel proteins into the mitochondrial outer membrane. SAMM50 has a molecular mass of approximately 50 kDa. It is predominantly expressed in tissues with high metabolic activity such as the liver and skeletal muscle where mitochondrial function is essential.
Biological function summary
SAMM50 functions as an integral part of the SAM complex which includes other essential subunits like SAM35 and SAM37. This complex facilitates the import and assembly of proteins into the mitochondrial outer membrane important for maintaining mitochondrial structure and function. By ensuring correct protein placement in the outer membrane SAMM50 supports mitochondrial membrane integrity and energy production processes.
Pathways
SAMM50 is involved in essential cellular pathways like mitochondrial protein import and metabolism. SAMM50 interacts with proteins such as TOM40 a component of the translocase of the outer membrane complex which assists in protein transport into mitochondrial compartments. These pathways contribute to the overall cellular energy balance and metabolic regulation reflecting the importance of SAMM50 in maintaining cellular homeostasis.
Alterations in SAMM50 expression or function relate to conditions like mitochondrial myopathy and liver disease. These disorders are linked to defective mitochondrial function due to improper protein import and assembly. SAMM50's interaction with other mitochondrial proteins such as TIM23 complex components influences these conditions by impacting the efficiency and functionality of mitochondrial protein import and assembly processes.