Abcam, ab247027, Anti-ABCA7 antibody

Size: 100µL
Rabbit Polyclonal ABCA7 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human Phospholipid-transporting ATPase ABCA7 aa 300-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Phospholipid-transporting ATPase ABCA7 aa 300-400. The exact immunogen used to generate this antibody is proprietary information.Q8IZY2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ABCA7 also known as ATP-binding cassette sub-family A member 7 functions as a transmembrane protein that plays a role in lipid transport and homeostasis. It belongs to the large ABC transporter family characterized by its ability to bind and hydrolyze ATP to transport various substrates across cellular membranes. The protein's mass is approximately 220 kDa. ABCA7 is mostly expressed in the brain and immune cells such as macrophages and microglia where it influences cellular lipid composition and related processes.
Biological function summary
The ABCA7 protein participates in lipid metabolism and immune response regulation. It is not part of a larger protein complex but functions in concert with other proteins to modulate processes such as phospholipid efflux and phagocytosis. Its role in macrophage-mediated lipid efflux affects the uptake and processing of lipids in cellular contexts which can impact inflammation and cellular signaling pathways connected to immunity.
Pathways
ABCA7 contributes significantly to lipid metabolism and immune response pathways. In lipid metabolism it shows functional interactions with proteins like ABCA1 which also participates in cholesterol efflux and HDL formation. In immune pathways it affects macrophage activity by regulating the phagocytic capability of these cells linking it to processes that influence inflammation and the immune system's ability to clear amyloid-beta peptides.
Mutations or alterations in ABCA7 expression have connections to Alzheimer's disease and atherosclerosis. In Alzheimer's disease ABCA7 alters the amyloid-beta clearance process in the brain an important feature of the disease's pathology with implications pointing to interaction with proteins like APOE a known risk factor. In atherosclerosis ABCA7 influences lipid processing and inflammation in arterial macrophages affecting the buildup of atherosclerotic plaques and related cardiovascular conditions.