Abcam, ab247133, Anti-ADAT3 antibody

Size: 100µL
Rabbit Polyclonal ADAT3 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human ADAT3 aa 250-350.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ADAT3 aa 250-350. The exact immunogen used to generate this antibody is proprietary information.Q96EY9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ADAT3 also known as ADAR3 or Adenosine Deaminase Acting on tRNA 3 is an enzyme with a molecular mass of approximately 30 kDa. It belongs to the family of ADAT enzymes which perform adenosine-to-inosine editing in RNA molecules. This protein expresses mainly in the brain and various other tissues indicating its availability across the body. The presence of ADAT3 is essential in regions where RNA editing plays a role in transcriptome diversity.
Biological function summary
The function of adenosine deamination significantly impacts RNA molecules. ADAT3 participates actively in the tRNA editing process. It becomes part of the ADAT complex which also includes ADAT2. This complex catalyzes the deamination of adenosine to inosine at the wobble position of certain tRNAs altering the genetic code potential during translation which contributes to the optimization of protein synthesis.
Pathways
ADAT3 has essential roles in tRNA modification and processing pathways. It impacts the expression and functionality of various genes by adjusting tRNA decoding accuracy. Through its role in RNA editing it relates closely to other RNA-editing ADAR proteins which share some mechanistic similarities. These proteins collaborate influencing broader pathways involving RNA metabolism and gene expression regulation.
Mutations or malfunctions in ADAT3 associate with intellectual disabilities specifically in conditions like neurodevelopmental disorders. The inability to perform adequate RNA editing can lead to defects in neural communication and development. Additionally ADAT3 is connected to specific proteins linked to cognitive function impairments indicating its significance in maintaining normal neurological function.