Abcam, ab247172, Anti-EPPK1 antibody

Size: 100µL
Rabbit Polyclonal EPPK1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human EPPK1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human EPPK1. The exact immunogen used to generate this antibody is proprietary information.P58107

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
EPPK1 also known as epiplakin is a large protein with a molecular mass of approximately 725 kDa. It is part of the plakin family and functions as a cytolinker protein. EPPK1 is fundamentally present in epithelial tissues and its expression is noted in various organs including the skin stomach and esophagus. This protein aids in the stabilization of cytoskeletal structures by crosslinking intermediate filaments within the cells.
Biological function summary
EPPK1 contributes to the structural integrity of epithelial cells by promoting filamentous network organization. It acts as a component in complexes that assemble the cytoskeleton's intermediate filament network significantly impacting cellular resilience and shape. EPPK1's interactions are important for maintaining cellular architecture and play an important role in cell adhesion processes.
Pathways
EPPK1 plays a significant role in both cytoskeletal organization and the cellular response to stress. It is part of pathways that involve keratin proteins which are necessary for maintaining epithelial scaffold resilience. Its interaction with proteins like desmoplakin further integrates EPPK1 into desmosome complex pathways that are essential for cohesion among epithelial cells.
Mutations or altered expression of EPPK1 have been linked to skin disorders such as epidermolysis bullosa and other keratin-associated conditions. This protein's anomalies might influence the desmosome machinery with possible interactions affecting other proteins like plakoglobin which is also associated with cellular adhesion integrity. Understanding EPPK1’s involvement in these conditions could pave the way for better therapeutic strategies.