Abcam, ab24751, Anti-ATP-binding cassette sub-family A member 3 antibody [3C9]

Size: 100µg
Anti-ATP-binding cassette sub-family A member 3 antibody [3C9] (ab24751) is a mouse monoclonal antibody detecting ATP-binding cassette sub-family A member 3 in IHC-P . Suitable for Mouse, Rat . - Over 20 publications - Trusted since 2005
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:3C9,
Isotype:IgG2a,
Carrier free:No,
Reacts with:Rat, Mouse,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
What is this antibody validated in?
Anti-ATP-binding cassette sub-family A member 3 antibody [3C9] (ab24751) is a mouse monoclonal antibody and is validated for use in Immunohistochemistry (IHC-P) in Mouse, Rat samples.
Trusted by the scientific community
Anti-ATP-binding cassette sub-family A member 3 [3C9] (ab24751) was first used in a scientific publication in 2005 and has been cited over 20 times in peer-reviewed journals.
Reviewed by scientists
Anti-ATP-binding cassette sub-family A member 3 [3C9] (ab24751) has over 5 independent reviews from customers.
Want a custom formulation?
This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ATP-binding cassette sub-family A member 3 (ABCA3) also known as Surfactant Metabolism Dysfunction Pulmonary 3 is a vital membrane protein weighing approximately 170 kDa. It belongs to the ATP-binding cassette (ABC) protein family which also includes family binding proteins that transport various molecules across cellular membranes. ABCA3 is mainly expressed in alveolar type II cells of the lung where it plays a significant mechanical role in surfactant metabolism. The protein facilitates the transport of lipids into lamellar bodies which are critical for surfactant storage and secretion.
Biological function summary
ABCA3 is essential for normal pulmonary function as it contributes to surfactant phospholipid homeostasis. It operates as a monomer and is part of a larger complex with other lipid-processing proteins. This interaction ensures the correct assembly and secretion of pulmonary surfactant which reduces surface tension in the alveoli and prevents alveolar collapse. The dysfunction or absence of ABCA3 can disrupt these processes compromising lung function.
Pathways
The role of ABCA3 is significant in the surfactant metabolism pathway and lipid transportation processes. The surfactant metabolism pathway ensures the availability of pulmonary surfactant necessary for efficient respiratory function. In these pathways ABCA3 intersects with other proteins such as ABCA1 and proteins involved in the phospholipid synthesis and transport processes ensuring lipid proteins are correctly assembled for surfactant formation.
ABCA3 mutations associate with respiratory diseases such as Neonatal Respiratory Distress Syndrome and interstitial lung disease. These diseases often result from impaired surfactant production and secretion caused by ABCA3 deficiency. Mutations in this protein can also lead to dysfunctional interactions with partner proteins like Surfactant Protein B (SP-B) and Surfactant Protein C (SP-C) further implicating its role in disease pathology. Understanding the connection between ABCA3 and these proteins reveals potential therapeutic targets for treating associated pulmonary conditions.