Abcam, ab248026, Anti-Tropomodulin 2 antibody [EPR6353] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal Tropomodulin 2 antibody. Carrier free. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR6353,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab248026 is the carrier-free version of
ab124833
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Tropomodulin 2 also known as Tmod2 is a protein that regulates the actin cytoskeleton dynamics by capping the pointed end of actin filaments. It prevents the addition and loss of actin subunits at this end stabilizing the filament structure. With an approximate molecular weight of 40 kDa Tropomodulin 2 is expressed mainly in the brain but levels vary in different neural tissues. This protein shares functional similarities with Tropomodulin isoforms particularly in its role of filament capping.
Biological function summary
The Tropomodulin 2 protein plays an important role in maintaining neural tissue integrity by influencing actin filament stability which affects cellular structures and signaling. Its association with other Tropomodulin proteins such as Tmod1 and Tmod4 suggests a multi-protein complex role in actin filament control. This actin stabilization is vital for synaptic structure and neuronal growth which are critical processes for effective neurocommunication.
Pathways
Tropomodulin 2 is actively involved in cytoskeletal dynamics that are important for pathways like those in neurodevelopment and synaptic function. Within these pathways it interacts with proteins such as tropomyosin which also binds to actin and enhances filament stabilization. Tropomodulin 2's function in these pathways impacts cellular morphology and motility impacting overall neurological development and maintenance.
Abnormal expression or dysfunction of Tropomodulin 2 has been linked to neurological disorders including schizophrenia and neurodegenerative diseases. Variations in expression affect not only actin filament dynamics but also impact proteins like β-III spectrin which associates with the cytoskeleton abnormalities seen in these disorders. This connection highlights the importance of Tropomodulin 2 in maintaining normal neural function and how disruptions can lead to disease progression.