Abcam, ab248045, Anti-ING1 antibody [EPR6788] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal ING1 antibody. Carrier free. Suitable for WB, Flow Cyt (Intra) and reacts with Human, Mouse, Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR6788,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Rat, Human,
Applications:Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab248045 is the carrier-free version of
ab124893
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The target ING1 also known as Inhibitor of Growth Protein 1 is a tumor suppressor protein with a mass of approximately 33 kDa. It functions mechanically by interacting with chromatin and transcriptional machinery to regulate cell growth apoptosis and DNA repair. ING1 localizes both in the nucleus and cytoplasm showing expression in various tissues but particularly in those with high proliferation rates.
Biological function summary
As part of the chromatin remodeling complex ING1 contributes to the regulation of gene expression by promoting histone acetylation. It affects the cellular response to stress and helps maintain genomic stability. Through interactions with other proteins in the complex ING1 influences cell cycle checkpoints and can induce apoptosis when DNA damage is irreparable.
Pathways
Several important cellular signaling cascades involve ING1. Notably it plays a role in the p53 signaling pathway where it collaborates with the tumor protein p53 to enhance transcriptional activation of downstream genes associated with growth arrest and apoptosis. Additionally ING1 participates in the PI3K/AKT pathway influencing cell survival and metabolism by modulating PI3K-mediated phosphorylation events.
Studies indicate that ING1 has significant links to cancer such as breast and colorectal cancer. Loss or mutation of ING1 disrupts its tumor suppressive functions leading to unchecked cellular proliferation. Moreover its interaction with the protein TP53 highlights its relevance in tumorigenesis as disruptions can impair p53-mediated tumor suppressive pathways further contributing to cancer development.