Abcam, ab248075, Anti-PCYOX1 antibody [EPR5611] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal PCYOX1 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR5611,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab248075 is the carrier-free version of
ab124966
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PCYOX1 also known as prenylcysteine oxidase 1 functions as an oxidase enzyme that specifically processes prenylated proteins by cleaving the thioether bond of prenylcysteines. This protein has a molecular weight of approximately 64 kDa. Expression of PCYOX1 is noted across various tissue types with marked presence in liver and kidney. Its localization suggests a possible involvement in cellular metabolism associated with lipid-modified proteins.
Biological function summary
The PCYOX1 protein enables degradation of prenylcysteine derivatives facilitating cellular processes related to lipid anchoring of signaling molecules. It is part of a larger complex responsible for prenylated protein turnover contributing to cellular regulation by modulating levels of signal transduction proteins anchored to membranes through prenylation.
Pathways
PCYOX1 participates in the isoprenoid metabolic pathway and is intricately linked to the post-translational modification pathway. This positions it alongside other prenylation-dependent proteins such as farnesylated and geranylgeranylated proteins which rely on similar modifications to localize to their functional membrane-bound states.
Alterations in PCYOX1 activity have connections to conditions like cancer and cardiovascular diseases. Dysregulation affects protein prenylation levels impacting pathways tied to oncogenes and proteins like Ras which is often implicated in malignancies. Likewise abnormal lipid metabolism associated with PCYOX1 links to cholesterol-related cardiovascular diseases influenced by protein interactions within these pathways.