Abcam, ab248299, Anti-ZNF136 antibody [EPR8225] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal ZNF136 antibody. Carrier free. Suitable for WB and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR8225,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab248299 is the carrier-free version of
ab129100
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZNF136 also known as Zinc Finger Protein 136 functions as a transcription factor due to its zinc finger domains which allow it to bind specific DNA sequences. It weighs approximately 65 kDa. This protein regulates the expression of target genes by interacting with DNA in a sequence-specific manner. Scientists find it predominantly expressed in the brain with lower levels detected in other tissues suggesting a specialized role in neural processes.
Biological function summary
ZNF136 regulates genes implicated in neuronal development and function. It may form part of transcriptional complexes but this requires further study. ZNF136 impacts the expression of genes necessary for maintaining neural network integrity and synaptic plasticity. Its activity supports proper cognitive function and neural communication indicating it plays a role in the regulation of brain homeostasis.
Pathways
ZNF136 integrates into neural gene regulation networks. It influences the Wnt signaling pathway which is important in neuronal development and function and interacts with proteins such as Beta-Catenin. Additionally ZNF136 participates in the transcriptional regulation of genes within the Notch signaling pathway working with proteins like RBPJ to fine-tune responses required for cell differentiation and maturation.
ZNF136 has associations with neurological conditions like schizophrenia and autism spectrum disorders. Abnormal expression or mutations in ZNF136 may disrupt neural communication pathways contributing to disease pathogenesis. It also seems related to dysregulation of proteins like NRXN1 which is implicated in synaptic connectivity providing insight into how ZNF136 alterations could influence these conditions.