Abcam, ab248311, Anti-FKBP38 antibody [EPR7441(2)] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal FKBP38 antibody. Carrier free. Suitable for ICC/IF, WB, Flow Cyt (Intra) and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR7441(2),
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WB, ICC/IF, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab248311 is the carrier-free version of
ab129113
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please
contact us
for more information.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FKBP38 also known as FK506 binding protein 8 is a member of the immunophilin protein family characterized by peptidyl-prolyl cis-trans isomerase activity. This protein weighs approximately 42 kDa and plays significant roles in various cellular processes. FKBP38 is mainly expressed in the mitochondria and endoplasmic reticulum where it regulates multiple signaling pathways through its interactions with other complex proteins.
Biological function summary
FKBP38 regulates apoptosis and cell survival mechanisms. It binds to and inhibits the anti-apoptotic proteins Bcl-2 and Bcl-xL forming a complex that influences mitochondrial integrity. This interaction is essential for maintaining cellular homeostasis and responding to stress signals. FKBP38's presence in these complexes highlights its role as an important modulator of cell death pathways contributing to balanced cell proliferation and survival.
Pathways
FKBP38 significantly affects the mTOR signaling pathway and the intrinsic apoptosis pathway. It interacts with important proteins such as Bcl-2 Bcl-xL and mTORC1 influencing cellular growth and apoptosis. FKBP38's regulation of mTOR signaling impacts protein synthesis cell growth and autophagy making it a critical factor in maintaining cellular metabolic balance.
FKBP38 has links to cancer and neurodegenerative diseases. Its modulation of apoptosis and cell proliferation relates to tumor growth and cancer progression where its interaction with Bcl-2 proteins becomes relevant. Additionally FKBP38's role in neurodegenerative diseases ties to its regulation of mitochondrial function where dysregulation leads to neuronal cell death. Understanding FKBP38's connections with these diseases helps in formulating potential therapeutic strategies targeting these important proteins and pathways.