Abcam, ab248615, Anti-Dymeclin antibody [EPR8789] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal Dymeclin antibody. Carrier free. Suitable for IHC-P, WB and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR8789,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab248615 is the carrier-free version of
ab133685
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please
contact us
for more information.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Dymeclin also known as Dym is a protein involved in cellular processes with a molecular weight of approximately 55kDa. This protein shows expression in various tissues but is especially present in the bone brain and cartilage. As a component of the endosomal system Dymeclin is important for maintaining proper cellular function. It assists in the stability and trafficking of lysosomes by interacting with intracellular compartments.
Biological function summary
Dymeclin participates in the regulation of skeletal development and neuronal functions. It acts within a larger protein complex that plays roles in maintaining cellular homeostasis particularly involving endosomal trafficking. Dymeclin interacts with other proteins to ensure the integrity of organelles and to modulate transport within the cell. This functionality is essential for proper growth and development affecting both bone density and brain function.
Pathways
Dymeclin finds involvement in the endocytic and lysosomal pathways. It connects to proteins like Rab7 which is significant for endosomal-lysosomal transport. Through these pathways Dymeclin influences the prevention of premature degradation of cellular components and assists in signal transduction processes. Its interactions within these pathways suggest a role in cellular stress response and adaptation by mediating protein sorting and degradation.
Mutations or dysfunctions related to Dymeclin lead to bone dysplasia and cognitive impairments. It is strongly associated with Smith-McCort dysplasia and Dyggve-Melchior-Clausen syndrome which involve skeletal abnormalities and intellectual disability. Dymeclin's connection to proteins involved in bone and brain development highlights its influence on the pathogenesis of these disorders emphasizing its role in both structural integrity and cognitive function.