Abcam, ab248632, Anti-Netrin G2 antibody [EPR4570(2)] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal Netrin G2 antibody. Carrier free. Suitable for Flow Cyt, WB and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR4570(2),
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WB, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab248632 is the carrier-free version of
ab133732
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Netrin G2 also known as Netrin-G2 or NTNG2 is a protein that weighs approximately 61 kDa. Netrin G2 belongs to the Netrin family and operates through binding with its receptors. It is expressed mainly in the central nervous system particularly in the brain regions like cortex and hippocampus. The protein facilitates communication across nerve cells by directing axon guidance and maintaining synaptic plasticity.
Biological function summary
This protein plays an essential role in neuronal development and synaptic connections. Netrin G2 acts as a part of cell surface signaling modules allowing interaction with other molecular entities. It binds to Netrin G2 ligands which helps stabilize long-range axonal trajectories. Due to this function Netrin G2 contributes to maintaining proper neural circuit assembly necessary for cognitive functions.
Pathways
Netrin G2 plays a part in the axon guidance and synaptogenesis pathways. It interacts with other guidance cues proteins such as DCC (Deleted in Colorectal Cancer) and UNC5B (Unc-5 Netrin Receptor B) which also participate in the regulation of axonal mapping. Throughout these pathways it ensures neurons reach their correct destination therefore influencing neural map precision and adaptability.
Mutations or dysregulation of Netrin G2 have associations with neurological conditions like schizophrenia and autism spectrum disorders. Alterations in Netrin G2 might affect its interaction with related proteins like DCC in these conditions. These disruptions can contribute to improper brain function by interfering with typical pathways of axonal targeting and synaptic stability.