Abcam, ab248873, Anti-CRCP antibody [EPR9670(B)] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal CRCP antibody. Carrier free. Suitable for ICC/IF, IP, WB, IHC-P and reacts with Human, Mouse, Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR9670(B),
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Rat, Human,
Applications:WB, IP, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab248873 is the carrier-free version of
ab139264
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The target CRCP also known as CGRP receptor component protein is a protein with a mass of approximately 148 kDa. It has a mechanical role in assisting the function of calcitonin gene-related peptide (CGRP) receptors. CRCP localizes in various tissues including the central nervous system and peripheral tissues like the heart and kidneys. Its expression is important for the proper signaling of peptide hormones in these areas.
Biological function summary
The CRCP influences the efficacy of CGRP receptor signaling. It functions as a part of the receptor complex aiding in the transmission of signals that control vasodilation and neuronal communication. CRCP does not act alone often associating with other components such as receptor activity-modifying proteins (RAMPs) and calcitonin receptor-like receptors (CLR) forming a fully functional CGRP receptor complex. This complex regulates important processes like blood flow and neurotransmitter release.
Pathways
CRCP participates in pathways related to neurovascular and endocrine signaling. It plays a role in the CGRP signaling pathway which involves significant proteins such as RAMP1 and CLR. These pathways contribute to the regulation of blood vessel tone and neuropeptide release impacting various physiological responses. CRCP's role in these pathways highlights its importance in maintaining proper cardiovascular and nervous system functioning.
CRCP is involved with migraine and cardiovascular diseases. Aberrations in CRCP or its associated signaling pathways may lead to dysregulation contributing to migraine pathophysiology. The protein's interaction with CGRP is well-documented in these conditions where the overactivation of the CGRP pathway can exacerbate symptoms. Moreover since CRCP is part of the vascular regulation mechanism any disruption in its function might contribute to cardiovascular disorders indicating a significant therapeutic target in these diseases.