Abcam, ab249017, Anti-MRPS16 antibody [EPR8835] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal MRPS16 antibody. Carrier free. Suitable for IHC-P, ICC/IF, WB and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR8835,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab249017 is the carrier-free version of
ab151693
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MRPS16 also known as mitochondrial ribosomal protein S16 is a component of the small subunit of the mitochondrial ribosome. This protein plays an important role in mitochondrial protein synthesis and exhibits a molecular mass of approximately 15 kDa. It is expressed in many tissues where energy production is essential such as the brain muscle and liver. It participates actively in the assembly of the mitochondrial ribosome facilitating the translation of ribosomal RNA into functional proteins important for mitochondrial function.
Biological function summary
Mitochondrial ribosomal protein S16 supports mitochondrial gene expression as part of the mitochondrial ribosomal small subunit. It works in concert with other mitochondrial ribosomal proteins to ensure the efficient translation of mitochondrial DNA-encoded proteins which are integral to oxidative phosphorylation. This protein functions as part of a larger complex the mammalian mitochondrial ribosome which maintains the cellular energy balance by promoting mitochondrial protein synthesis.
Pathways
MRPS16 is an important player in mitochondrial translation and energy production pathways. It contributes to the proper functioning of the oxidative phosphorylation pathway which is critical for ATP generation in cells. MRPS16 functionally interacts with other mitochondrial ribosomal proteins such as MRPS18 in these pathways enabling the full capability of the mitochondrial translation machinery to synthesize proteins necessary for electron transport chain assembly and maintenance.
Mitochondrial dysfunction involving MRPS16 can contribute to conditions such as mitochondrial encephalomyopathy and Leigh syndrome. These disorders often stem from impaired mitochondrial function and energy production where MRPS16 mutation may disrupt core cellular energy processes. The protein's relationship to these diseases highlights possible associations with related mitochondrial proteins like MRPL3 which may share overlapping roles or compensatory mechanisms in mitochondrial ribosome formation and function.