Abcam, ab249051, Anti-AIBZIP antibody [EPR7382] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal AIBZIP antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR7382,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab249051 is the carrier-free version of
ab151736
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
AIBZIP also known as Activating Immune Response Protein BZIP is a transcription factor involved in regulating gene expression. This protein with a molecular mass of approximately 45 kDa plays an important role in cellular functioning. Researchers have observed AIBZIP expression mainly in the immune cells including B and T lymphocytes. It regulates genes involved in immune responses by binding to DNA at specific sites assisting in the control of gene transcription.
Biological function summary
AIBZIP is a regulator of immune cell communication and response. AIBZIP forms a complex with other bZIP family proteins enabling it to influence a wide range of cellular processes. AIBZIP modulates expression of cytokines and other immunologically relevant genes. Proper function of AIBZIP ensures cells can effectively respond to pathogens and maintain immune homeostasis.
Pathways
AIBZIP acts in the NF-kB signaling pathway and JAK-STAT pathway both important for immune response and inflammation regulation. It interacts with proteins like RelA in the NF-kB pathway which modulates inflammatory responses and STAT3 in the JAK-STAT pathway that affects cellular growth and differentiation. Through these pathways AIBZIP influences many immune system functions and contributes to the regulation of immune cell activity.
AIBZIP impacts conditions like autoimmune disorders and certain cancers. Dysregulation of AIBZIP can lead to improper immune responses contributing to autoimmune diseases such as lupus. It also links to cancerous processes by affecting the immune system’s ability to fight tumor cells interacting with proteins like p53 that are important for cell cycle regulation. Understanding these interactions can help in developing targeted therapies for such diseases.