Abcam, ab249162, Anti-PPP3CC antibody [EPR10601] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal PPP3CC antibody. Carrier free. Suitable for WB and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR10601,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab249162 is the carrier-free version of
ab154863
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The PPP3CC gene encodes the catalytic subunit of the protein phosphatase 3 also known as calcineurin gamma which weighs approximately 58 kDa. This enzyme acts as a calcium/calmodulin-dependent serine/threonine phosphatase that modulates various cellular functions by dephosphorylating target proteins. It is widely expressed across various tissues but its presence is significant in the brain where it plays an important part in neural signaling and synaptic plasticity.
Biological function summary
The protein phosphatase 3 complex involves PPP3CC which contributes to numerous cellular signaling pathways by regulating intracellular levels of calcium. This regulation impacts synaptic transmission neuronal excitability and immune responses. In the neuronal context it helps modulate pathways associated with long-term potentiation and learning by influencing the recruitment and function of neurotransmitter receptors.
Pathways
PPP3CC contributes a regulatory role to the calcium signaling pathway and the calcineurin-NFAT pathway. In these pathways it interacts with and dephosphorylates the NFAT transcription factors influencing gene transcription related to immune response and neural activities. Through these interactions it shares functional relationships with other proteins like NFAT and calmodulin which also participate in these pathways.
Irregular activity of PPP3CC links to neurological disorders such as Alzheimer’s disease and schizophrenia. Altered calcineurin signaling involving the PPP3CC subunit associates with disrupted synaptic functions and neuronal communication in these conditions. Furthermore in Alzheimer's disease the dysregulation may involve other proteins like tau or amyloid precursor protein influencing disease progression and severity.