Abcam, ab249180, Anti-ZFYVE19 antibody [EPR9789] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal ZFYVE19 antibody. Carrier free. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR9789,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab249180 is the carrier-free version of
ab155085
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZFYVE19 also known as Zinc Finger FYVE-type Containing 19 or ANKFY1 is a protein characterized by the presence of an FYVE domain and ankyrin repeats. This protein has a molecular mass of approximately 104 kDa. ZFYVE19 is expressed broadly in human tissues with high expression levels in the testis brain and heart. Mechanically it plays a pivotal role in vesicular trafficking where the FYVE domain is often involved in binding phosphatidylinositol 3-phosphate on endosomal membranes assisting in the regulation of endosomal-lysosomal sorting.
Biological function summary
This protein plays a significant role in cellular processes related to membrane trafficking and endocytosis. It often participates in protein complexes related to intracellular transport ensuring proper vesicular movements within the cell. ZFYVE19 is known to associate with various molecules that facilitate communication between different cellular compartments. These interactions are essential for cellular homeostasis and affect diverse processes such as signal transduction and nutrient uptake.
Pathways
ZFYVE19 integrates itself in the endosomal-lysosomal pathway and the phosphoinositide signaling pathway. These pathways are important for maintaining cellular lipid homeostasis and endosome maturation. In its function ZFYVE19 interacts with proteins such as EEA1 a well-known early endosome antigen and RAB5A a small GTPase that regulates endocytic vesicle fusion. These interactions help orchestrate the dynamics of membrane trafficking and signal transduction.
Disruptions in ZFYVE19 function have been associated with neurodegenerative diseases and certain cancers. In the context of neurodegenerative diseases a malfunction in endosomal-lysosomal sorting can lead to the accumulation of cellular debris similar to defects observed in disorders like Alzheimer's disease. ZFYVE19's interplay with clathrin which is critical for endocytosis can influence tumorigenesis with alterations in this process contributing to oncogenic transformations in some forms of cancer. Understanding the roles played by ZFYVE19 in these diseases provides insight into potential therapeutic targets.