Abcam, ab249237, Anti-RPS19 antibody [EPR10422] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal RPS19 antibody. Carrier free. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR10422,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab249237 is the carrier-free version of
ab155994
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RPS19 also known as Ribosomal Protein S19 is a component of the small 40S ribosomal subunit. It has a molecular weight of approximately 16 kDa. This protein is widely expressed in many tissues including the bone marrow and spleen which are important for hematopoiesis. RPS19 plays a mechanical role in ensuring the formation and function of ribosomes which are essential for protein synthesis. By participating in ribosome assembly it supports the translational machinery of cells.
Biological function summary
Ribosomal protein S19 holds a critical place in ribosome biogenesis. It is part of the ribosomal protein family and works together with other ribosomal proteins to create functional ribosomes necessary for cellular protein synthesis. As part of the 40S ribosomal subunit RPS19 facilitates the accurate translation of mRNA into proteins which is fundamental for cell growth and proliferation. The 40S subunit alongside the 60S subunit completes the formation of the functional ribosome.
Pathways
Ribosomal protein S19 contributes to the essential process of translation an important pathway within cell biology. It plays a part in the ribosome assembly pathway a pivotal process necessary for cell survival and function. RPS19 interacts closely with other ribosomal proteins such as RPS24 and RPS14 ensuring the proper assembly and functionality of the ribosomal subunits. These interactions are integral to maintaining cellular homeostasis and protein production.
Ribosomal protein S19 is associated with Diamond-Blackfan Anemia a rare genetic anemia caused by ribosomal protein mutations. This condition arises due to defective ribosome biogenesis leading to impaired erythropoiesis. Mutations in RPS19 reduce the ribosome's capacity to synthesize proteins specifically affecting red blood cell production. Additionally the protein is related to other ribosomal anomalies that connect to various bone marrow failure syndromes.