Abcam, ab249299, Anti-TPST2 antibody [EPR10569] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal TPST2 antibody. Carrier free. Suitable for IHC-P, WB and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR10569,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab249299 is the carrier-free version of
ab157191
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TPST2 also known as tyrosylprotein sulfotransferase 2 is an enzyme that transfers a sulfate group to the tyrosine residues of proteins. It has an approximate mass of 54 kDa. TPST2 is expressed in various tissues including the pancreas thyroid and lung. The activity of TPST2 is essential for the post-translational modification process which is important for protein function and interaction.
Biological function summary
Tyrosine sulfation by TPST2 enhances protein-protein interactions impacting various cellular processes. TPST2 often forms a part of larger enzyme complexes within the Golgi apparatus facilitating the sulfation of substrates. This post-translational modification is important for modulating the activity and binding affinity of many proteins with consequences on cell signaling and communication.
Pathways
The enzyme TPST2 participates in the sulfation pathway impacting protein function and regulation within cells. It works alongside proteins such as heparan sulfate proteoglycans (HSPGs) in modulating biological processes. Tyrosine sulfation conducted by TPST2 plays a role in the immune response pathway assisting in the regulation of leukocyte adhesion and signaling.
Aberrations in TPST2 expression or function can connect to several conditions. Research has indicated potential links between TPST2 and inflammatory disorders. Disorders like rheumatoid arthritis may show association due to altered sulfation patterns impacting immune cell interactions. TPST2 has also been studied in relation to cancer where modification of cell surface proteins may influence tumor progression and metastasis.