Abcam, ab249415, Anti-PSMG1 antibody [EPR10223] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal PSMG1 antibody. Carrier free. Suitable for IHC-P, ICC/IF, IP, WB and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR10223,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:ICC/IF, WB, IP, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab249415 is the carrier-free version of
ab167396
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PSMG1 also known as Proteasome Assembly Chaperone 1 or PAC1 is involved in the assembly of the 20S proteasome complex which is essential for protein degradation. This protein has a mass of approximately 36 kDa. Researchers have identified its expression primarily in the cytoplasm and nucleus of various cell types across different human tissues suggesting a broad functional role.
Biological function summary
PSMG1 participates as a chaperone that guides the proper assembly of the proteasome complex. It partners with other chaperones such as PSMG2 to help ensure that the proteasome particles achieve their correct configuration. By doing so it maintains protein homeostasis within cells which is essential for cellular function and survival. Its activity is critical for regulating the protein quality control system.
Pathways
PSMG1 plays a role in the ubiquitin-proteasome pathway which is responsible for protein degradation and turnover. This protein also interacts with other components of the pathway such as ubiquitin and various proteasome subunits. PSMG1's function within these pathways highlights its interaction with proteins involved in regulating the cell cycle and apoptosis ensuring cells respond properly to stress and damage.
PSMG1 has been linked to conditions such as cancer and neurodegenerative diseases. Abnormalities in its function can lead to disruptions in the proteasome pathway affecting proteins like p53 an important regulator of cell cycle and apoptosis. These links point to the importance of PSMG1 in maintaining cellular integrity and underline its significance in disease progression offering potential insights for therapeutic targets.