Abcam, ab249493, Anti-Zmat2 antibody [EPR11136] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal ZMAT2 antibody. Carrier free. Suitable for IHC-P, ICC/IF, WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR11136,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab249493 is the carrier-free version of
ab169541
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Zmat2 also known as Zinc finger matrin-type protein 2 plays a role in RNA processing. This protein has a mass of approximately 37 kDa. It shows expression in most tissues with higher levels in certain areas of the brain and reproductive organs. The protein contains a zinc finger domain which facilitates binding to RNA and possibly other molecular components suggesting its involvement in cellular processes requiring precise regulation.
Biological function summary
Zmat2 influences the maturation and modification of mRNA. It serves as part of the spliceosome complex which is responsible for the splicing of pre-mRNA and is essential for the regulation of gene expression. Zmat2 contributes to the appropriate removal of introns and joining of exons ensuring the production of functional RNA transcripts. Its actions are important for the maintenance of cellular function and response to environmental cues.
Pathways
Several components in the RNA splicing machinery are associated with Zmat2. Among these the spliceosome assembly and mRNA surveillance pathways are notably significant. Zmat2 works in conjunction with PRPF8 and several small nuclear ribonucleoproteins (snRNPs) which are necessary for the assembly of the spliceosomal complex. These interactions ensure effective and reliable mRNA processing and turnover.
Abnormal functioning of Zmat2 may have a connection with certain neurological conditions. Disruption in RNA splicing can lead to the accumulation of faulty proteins potentially resulting in diseases like amyotrophic lateral sclerosis (ALS) and some neurodegenerative disorders. The involvement of Zmat2 in pathways with other proteins like FUS and TDP-43 which are linked to these conditions highlights its importance in maintaining neural health.