Abcam, ab249586, Anti-PDE7B antibody [EPR11491] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal PDE7B antibody. Carrier free. Suitable for IHC-P, ICC/IF, WB, Flow Cyt (Intra) and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR11491,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WB, IHC-P, Flow Cyt (Intra), ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab249586 is the carrier-free version of
ab170914
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Phosphodiesterase 7B (PDE7B) is an enzyme that plays an important role in the hydrolysis of cyclic adenosine monophosphate (cAMP) a critical second messenger in cellular signaling. Also known as HCP1 PDE7B has a molecular mass of approximately 49 kDa. It is expressed in various tissues throughout the body with marked expression in the brain particularly in regions associated with cognition and motor function. This expression pattern suggests that PDE7B may have specialized roles in neural activities and processes.
Biological function summary
The involvement of PDE7B in the hydrolysis of cAMP points to its role in signal transduction pathways that regulate physiological responses. By degrading cAMP PDE7B modulates signal strength and duration influencing cellular responses such as proliferation differentiation and survival. While there is no evidence PDE7B forms part of a larger protein complex its action interacts with multiple signaling cascades making it an integral part of cellular response machinery.
Pathways
The functions of PDE7B are integral to cAMP-specific signaling pathways such as the PKA (protein kinase A) signaling cascade. By regulating cAMP levels PDE7B indirectly influences the activity of PKA which phosphorylates various target proteins to execute cellular functions. PDE7B is closely related to other phosphodiesterases like PDE4 and PDE1 in these pathways which also target cAMP but have different expression and activity regulation.
PDE7B presents potential involvement in neurological and inflammatory conditions. Abnormal PDE7B function or expression could contribute to disorders such as Parkinson's disease where altered signaling may impact neuronal survival and dopamine regulation. Moreover by modulating cAMP levels PDE7B might also associate with chronic inflammatory disorders wherein dysregulated immune responses play an important role. Research into PDE7B's interactions with other proteins like PDE4 could uncover new therapeutic strategies for managing these conditions.