Abcam, ab249590, Anti-SLAP2 antibody [EPR8083(2)] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal SLAP2 antibody. Carrier free. Suitable for ICC/IF, IP, WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR8083(2),
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:Flow Cyt (Intra), ICC/IF, IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab249590 is the carrier-free version of
ab170918
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Src-like adapter protein 2 (SLAP2) also known as SLAP2 functions as an adaptor protein involved in signal transduction. It mediates interactions between membrane receptors and intracellular signaling components. SLAP2 is a protein of approximately 32 kDa and expression levels vary across different tissues including high expression in immune cells such as lymphocytes and macrophages. The protein has SH2 and SH3 domains which allow it to bind to phosphorylated tyrosines on its target proteins facilitating their degradation or modification.
Biological function summary
SLAP2 has a major role in regulating the immune response. By forming complexes with the components of the signal transduction machinery SLAP2 modulates the activity of key receptors such as the T-cell receptor (TCR) and B-cell receptor (BCR). These interactions influence cellular responses such as proliferation differentiation and apoptosis. Through its action SLAP2 acts as a negative regulator preventing overactivation of immune responses and maintaining homeostasis.
Pathways
Studies have shown that SLAP2 participates in both the T-cell receptor signaling pathway and the B-cell receptor signaling pathway. In these pathways SLAP2 interacts with kinases associated with these receptors such as Lck and Fyn influencing downstream signaling events. SLAP2 can inhibit excessive activation of these pathways by promoting the degradation of key signaling molecules ensuring that cells respond appropriately to external signals during immune activation.
SLAP2 has been linked to certain types of cancer and autoimmune diseases. For example alterations in SLAP2 expression or function may contribute to lymphomas where disrupted signaling processes lead to uncontrolled cell growth. In autoimmune diseases aberrant SLAP2 activity could result in improper immune cell activation potentially linked to proteins like ZAP-70 which are also involved in disease modulation. Understanding SLAP2's regulation and interaction with signaling proteins could offer insights for therapeutic interventions in these conditions.