Abcam, ab249625, Anti-GNL2 antibody [EPR11479] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal GNL2 antibody. Carrier free. Suitable for WB and reacts with Mouse, Rat, Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR11479,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab249625 is the carrier-free version of
ab170960
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GNL2 also known as nucleolar GTP-binding protein 2 functions mechanistically as a GTP-binding protein involved in ribosome biogenesis. With a mass of approximately 68 kDa GNL2 participates in nucleolar processes. Expression of GNL2 occurs broadly within tissues but shows notable presence in proliferative cells. It belongs to the MMR1/HSR1 GTP-binding protein family.
Biological function summary
GNL2 interacts as part of the nucleolar complex that contributes to ribosome assembly and maturation. It assists in the stabilization and processing of ribosomal RNA precursors aiding in the production of functional ribosomes necessary for protein synthesis. This connection highlights its role in cellular proliferation and homeostasis particularly within fast-dividing cells.
Pathways
GNL2 interacts with several important cellular processes beyond its primary role in ribosome biogenesis. It integrates into the cell cycle regulatory pathway influencing cell cycle progression and growth. GNL2 also shows involvement with proteins such as nucleolin and nucleophosmin partners essential for its function in ribosome maturation and the regulation of nucleolar structure.
GNL2 exerts influence on conditions associated with abnormal cell proliferation. It has a connection to cancers given its role in accelerating ribosome biogenesis and supporting high proliferation rates in tumor cells. GNL2's dysregulation links it with oncogenic processes often interacting with proteins like p53 an essential regulator in cancer pathways. Additionally aberrant GNL2 expression might relate to disorders involving disrupted cell cycle control.