Abcam, ab249712, Anti-CAMK1D antibody [EPR3536(2)] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal KCC1D antibody. Carrier free. Suitable for ICC/IF, WB and reacts with Human, Mouse samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR3536(2),
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab249712 is the carrier-free version of
ab172618
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CAMK1D also known as Calcium/Calmodulin-dependent protein kinase ID plays a role as a serine/threonine-specific protein kinase. This protein is part of the calcium/calmodulin-dependent protein kinase family. It has a mass of approximately 45 kDa. CAMK1D expression occurs in various tissues including the brain liver and muscle. It functions by phosphorylating downstream targets in response to the changes in calcium levels which ultimately influences numerous cellular processes.
Biological function summary
CAMK1D participates in neuronal development and immune responses. It plays an important role in the regulation of gene expression and cytoskeletal rearrangement. CAMK1D does not typically form complexes but it interacts with other proteins to perform its functions. Its activity is regulated by the binding of calmodulin in response to increased intracellular calcium levels which activates its kinase activity leading to phosphorylation of target proteins.
Pathways
CAMK1D actively integrates into the calcium signaling pathway as well as the MAPK signaling pathway. Through these pathways it interacts with several proteins like CREB and acts to mediate the effects of calcium on cellular activities. Its role in calcium signaling links it to various responses such as cellular growth apoptosis and differentiation. CAMK1D shares functional interactions with other kinases in these pathways aiding in signal transduction and cellular response regulation.
CAMK1D has been associated with certain types of cancer and diabetes. Abnormal regulation of CAMK1D expression or activity can lead to dysregulated cellular processes that contribute to the development of these conditions. In cancer CAMK1D may interact with proteins like p53 which is critical for cell cycle regulation and apoptosis. In diabetes its interaction with insulin signaling pathways highlights its potential role in glucose metabolism and homeostasis.