Abcam, ab249718, Anti-Ninjurin2 antibody [EPR12038] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal Ninjurin2 antibody. Carrier free. Suitable for IP, WB and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12038,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab249718 is the carrier-free version of
ab172627
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Ninjurin2 also known as NINJ2 is a member of the Ninjurin protein family. It weighs approximately 16 kDa and mainly expresses in nerve tissues and some peripheral organs. Ninjurin2 is a transmembrane protein that plays a role in cell adhesion and migration. It interacts with the extracellular matrix and supports the interaction between cells. The protein’s structural features include hydrophobic domains that aid in this binding.
Biological function summary
Ninjurin2 contributes to the repair and regeneration of nerve tissues. It actively engages in cellular communication promoting neurogenesis and synapse formation in the nervous system. Ninjurin2 is not known as part of a larger protein complex but it functions alongside molecules involved in cellular regeneration. Research suggests a significant involvement in the modulation of immune responses interfacing with immune cells during injury response.
Pathways
Ninjurin2 functions within important neural and immune signaling routes. It participates in the neuroplasticity pathway which is critical for healing neural injuries and supports the immune surveillance system by communicating with cytokines. The protein works closely with other related proteins like Ninjurin1 which shares similar cellular roles as well as integrins which help mediate its cellular adhesion functions.
Ninjurin2 has been linked to conditions related to nerve damage and inflammation such as neurodegenerative disorders and chronic inflammatory diseases. In cases of neurodegenerative disorders abnormal Ninjurin2 function may affect neuron durability and regeneration. Connections with inflammatory diseases arise due to its role in immune response modulation. Ninjurin2’s interaction with other proteins in these contexts notably MyD88 affects cellular responses to injury and subsequent recovery processes.